Mechanism of action of tin-containing fluoride solutions as anti-erosive agents in dentine - an in vitro tin-uptake, tissue loss, and scanning electron microscopy study.
Identifieur interne : 000344 ( Main/Exploration ); précédent : 000343; suivant : 000345Mechanism of action of tin-containing fluoride solutions as anti-erosive agents in dentine - an in vitro tin-uptake, tissue loss, and scanning electron microscopy study.
Auteurs : Carolina Ganss [Allemagne] ; Martin Hardt ; Adrian Lussi ; Ann-Kristin Cocks ; Joachim Klimek ; Nadine SchlueterSource :
- European journal of oral sciences [ 1600-0722 ] ; 2010.
Descripteurs français
- KwdFr :
- Acide citrique (effets indésirables), Collagenases (pharmacologie), Dentine (effets des médicaments et des substances chimiques), Dentine (métabolisme), Dentine (ultrastructure), Diamines (pharmacologie), Déminéralisation dentaire (anatomopathologie), Déminéralisation dentaire (métabolisme), Déminéralisation dentaire (prévention et contrôle), Facteurs temps (MeSH), Fluorure de sodium (pharmacologie), Fluorures (pharmacologie), Fluorures d'étain (pharmacocinétique), Fluorures d'étain (pharmacologie), Humains (MeSH), Imagerie tridimensionnelle (MeSH), Microscopie électronique à balayage (MeSH), Précipitation chimique (MeSH), Reminéralisation des dents (MeSH), Spectrométrie d'émission X (MeSH), Traitement d'image par ordinateur (MeSH), Érosion dentaire (anatomopathologie), Érosion dentaire (métabolisme), Érosion dentaire (prévention et contrôle), Étain (pharmacocinétique), Étain (pharmacologie).
- MESH :
- anatomopathologie : Déminéralisation dentaire, Érosion dentaire.
- effets des médicaments et des substances chimiques : Dentine.
- effets indésirables : Acide citrique.
- métabolisme : Dentine, Déminéralisation dentaire, Érosion dentaire.
- pharmacocinétique : Fluorures d'étain, Étain.
- pharmacologie : Collagenases, Diamines, Fluorure de sodium, Fluorures, Fluorures d'étain, Étain.
- prévention et contrôle : Déminéralisation dentaire, Érosion dentaire.
- ultrastructure : Dentine, Facteurs temps, Humains, Imagerie tridimensionnelle, Microscopie électronique à balayage, Précipitation chimique, Reminéralisation des dents, Spectrométrie d'émission X, Traitement d'image par ordinateur.
English descriptors
- KwdEn :
- Chemical Precipitation (MeSH), Citric Acid (adverse effects), Collagenases (pharmacology), Dentin (drug effects), Dentin (metabolism), Dentin (ultrastructure), Diamines (pharmacology), Fluorides (pharmacology), Humans (MeSH), Image Processing, Computer-Assisted (MeSH), Imaging, Three-Dimensional (MeSH), Microscopy, Electron, Scanning (MeSH), Sodium Fluoride (pharmacology), Spectrometry, X-Ray Emission (MeSH), Time Factors (MeSH), Tin (pharmacokinetics), Tin (pharmacology), Tin Fluorides (pharmacokinetics), Tin Fluorides (pharmacology), Tooth Demineralization (metabolism), Tooth Demineralization (pathology), Tooth Demineralization (prevention & control), Tooth Erosion (metabolism), Tooth Erosion (pathology), Tooth Erosion (prevention & control), Tooth Remineralization (MeSH).
- MESH :
- chemical , adverse effects : Citric Acid.
- chemical , pharmacokinetics : Tin, Tin Fluorides.
- chemical , pharmacology : Collagenases, Diamines, Fluorides, Sodium Fluoride, Tin, Tin Fluorides.
- drug effects : Dentin.
- metabolism : Dentin, Tooth Demineralization, Tooth Erosion.
- pathology : Tooth Demineralization, Tooth Erosion.
- prevention & control : Tooth Demineralization, Tooth Erosion.
- ultrastructure : Dentin.
- Chemical Precipitation, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Microscopy, Electron, Scanning, Spectrometry, X-Ray Emission, Time Factors, Tooth Remineralization.
Abstract
Solutions containing tin and fluoride exhibit remarkable anti-erosive properties with tin ions as a major agent. To elucidate its mechanism of action in dentine, the tin uptake on and in the tissue was investigated and related to histological findings and substance loss. Samples were treated twice daily, each treatment lasting for 2 min, with fluoride solutions [pH 4.5; 1,500 parts per million (p.p.m.) F] containing 2,100, 1,400, or 400 p.p.m. Sn as SnCl(2). In experiments 1 and 2, samples were eroded with citric acid (pH 2.3) six times each day, each treatment lasting for 5 min; in experiment 2, the demineralized organic matrix was continuously digested by collagenase; in experiment 3, no erosive challenges were performed. Sample surfaces and cross-sections were investigated using energy dispersive X-ray spectroscopy, scanning electron microscopy, and profilometry. Surface retention of tin was found in almost all treatment groups and was highest in experiment 2. On cross-sections, tin was retained within the organic matrix; in mineralized areas, tin was found mainly within a depth of 10 mum. Test solutions inhibited substance loss significantly; in experiment 2, the effect was dose-dependent. Erosion inhibition seemed to depend mainly on the incorporation of tin in the mineralized dentine when the organic portion was preserved, but on surface precipitation when the organic portion was continuously digested.
DOI: 10.1111/j.1600-0722.2010.00742.x
PubMed: 20662911
Affiliations:
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(metabolism)</term><term>Tooth Demineralization (pathology)</term><term>Tooth Demineralization (prevention & control)</term><term>Tooth Erosion (metabolism)</term><term>Tooth Erosion (pathology)</term><term>Tooth Erosion (prevention & control)</term><term>Tooth Remineralization (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide citrique (effets indésirables)</term><term>Collagenases (pharmacologie)</term><term>Dentine (effets des médicaments et des substances chimiques)</term><term>Dentine (métabolisme)</term><term>Dentine (ultrastructure)</term><term>Diamines (pharmacologie)</term><term>Déminéralisation dentaire (anatomopathologie)</term><term>Déminéralisation dentaire (métabolisme)</term><term>Déminéralisation dentaire (prévention et contrôle)</term><term>Facteurs temps (MeSH)</term><term>Fluorure de sodium (pharmacologie)</term><term>Fluorures (pharmacologie)</term><term>Fluorures d'étain (pharmacocinétique)</term><term>Fluorures d'étain (pharmacologie)</term><term>Humains (MeSH)</term><term>Imagerie tridimensionnelle (MeSH)</term><term>Microscopie électronique à balayage (MeSH)</term><term>Précipitation chimique (MeSH)</term><term>Reminéralisation des dents (MeSH)</term><term>Spectrométrie d'émission X (MeSH)</term><term>Traitement d'image par ordinateur (MeSH)</term><term>Érosion dentaire (anatomopathologie)</term><term>Érosion dentaire (métabolisme)</term><term>Érosion dentaire (prévention et contrôle)</term><term>Étain (pharmacocinétique)</term><term>Étain (pharmacologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Citric Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Tin</term><term>Tin Fluorides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Collagenases</term><term>Diamines</term><term>Fluorides</term><term>Sodium Fluoride</term><term>Tin</term><term>Tin Fluorides</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Déminéralisation dentaire</term><term>Érosion dentaire</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Dentin</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Dentine</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Acide citrique</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Dentin</term><term>Tooth Demineralization</term><term>Tooth Erosion</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Dentine</term><term>Déminéralisation dentaire</term><term>Érosion dentaire</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Tooth Demineralization</term><term>Tooth Erosion</term></keywords><keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Fluorures d'étain</term><term>Étain</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Collagenases</term><term>Diamines</term><term>Fluorure de sodium</term><term>Fluorures</term><term>Fluorures d'étain</term><term>Étain</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Tooth Demineralization</term><term>Tooth Erosion</term></keywords><keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Déminéralisation dentaire</term><term>Érosion dentaire</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Dentin</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Chemical Precipitation</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Imaging, Three-Dimensional</term><term>Microscopy, Electron, Scanning</term><term>Spectrometry, X-Ray Emission</term><term>Time Factors</term><term>Tooth Remineralization</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="fr"><term>Dentine</term><term>Facteurs temps</term><term>Humains</term><term>Imagerie tridimensionnelle</term><term>Microscopie électronique à balayage</term><term>Précipitation chimique</term><term>Reminéralisation des dents</term><term>Spectrométrie d'émission X</term><term>Traitement d'image par ordinateur</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Solutions containing tin and fluoride exhibit remarkable anti-erosive properties with tin ions as a major agent. To elucidate its mechanism of action in dentine, the tin uptake on and in the tissue was investigated and related to histological findings and substance loss. Samples were treated twice daily, each treatment lasting for 2 min, with fluoride solutions [pH 4.5; 1,500 parts per million (p.p.m.) F] containing 2,100, 1,400, or 400 p.p.m. Sn as SnCl(2). In experiments 1 and 2, samples were eroded with citric acid (pH 2.3) six times each day, each treatment lasting for 5 min; in experiment 2, the demineralized organic matrix was continuously digested by collagenase; in experiment 3, no erosive challenges were performed. Sample surfaces and cross-sections were investigated using energy dispersive X-ray spectroscopy, scanning electron microscopy, and profilometry. Surface retention of tin was found in almost all treatment groups and was highest in experiment 2. On cross-sections, tin was retained within the organic matrix; in mineralized areas, tin was found mainly within a depth of 10 mum. Test solutions inhibited substance loss significantly; in experiment 2, the effect was dose-dependent. Erosion inhibition seemed to depend mainly on the incorporation of tin in the mineralized dentine when the organic portion was preserved, but on surface precipitation when the organic portion was continuously digested.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20662911</PMID><DateCompleted><Year>2010</Year><Month>12</Month><Day>08</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1600-0722</ISSN><JournalIssue CitedMedium="Internet"><Volume>118</Volume><Issue>4</Issue><PubDate><Year>2010</Year><Month>Aug</Month></PubDate></JournalIssue><Title>European journal of oral sciences</Title><ISOAbbreviation>Eur J Oral Sci</ISOAbbreviation></Journal><ArticleTitle>Mechanism of action of tin-containing fluoride solutions as anti-erosive agents in dentine - an in vitro tin-uptake, tissue loss, and scanning electron microscopy study.</ArticleTitle><Pagination><MedlinePgn>376-84</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1600-0722.2010.00742.x</ELocationID><Abstract><AbstractText>Solutions containing tin and fluoride exhibit remarkable anti-erosive properties with tin ions as a major agent. To elucidate its mechanism of action in dentine, the tin uptake on and in the tissue was investigated and related to histological findings and substance loss. Samples were treated twice daily, each treatment lasting for 2 min, with fluoride solutions [pH 4.5; 1,500 parts per million (p.p.m.) F] containing 2,100, 1,400, or 400 p.p.m. Sn as SnCl(2). In experiments 1 and 2, samples were eroded with citric acid (pH 2.3) six times each day, each treatment lasting for 5 min; in experiment 2, the demineralized organic matrix was continuously digested by collagenase; in experiment 3, no erosive challenges were performed. Sample surfaces and cross-sections were investigated using energy dispersive X-ray spectroscopy, scanning electron microscopy, and profilometry. Surface retention of tin was found in almost all treatment groups and was highest in experiment 2. On cross-sections, tin was retained within the organic matrix; in mineralized areas, tin was found mainly within a depth of 10 mum. Test solutions inhibited substance loss significantly; in experiment 2, the effect was dose-dependent. Erosion inhibition seemed to depend mainly on the incorporation of tin in the mineralized dentine when the organic portion was preserved, but on surface precipitation when the organic portion was continuously digested.</AbstractText><CopyrightInformation>(c) 2010 The Authors. Journal compilation (c) 2010 Eur J Oral Sci.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ganss</LastName><ForeName>Carolina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Conservative and Preventive Dentistry, Dental Clinic, Justus Liebig University Giessen, Giessen, Germany. carolina.ganss@dentist.med.uni-giessen.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hardt</LastName><ForeName>Martin</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Lussi</LastName><ForeName>Adrian</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Cocks</LastName><ForeName>Ann-Kristin</ForeName><Initials>AK</Initials></Author><Author ValidYN="Y"><LastName>Klimek</LastName><ForeName>Joachim</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Schlueter</LastName><ForeName>Nadine</ForeName><Initials>N</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Eur J Oral Sci</MedlineTA><NlmUniqueID>9504563</NlmUniqueID><ISSNLinking>0909-8836</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003959">Diamines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014002">Tin Fluorides</NameOfSubstance></Chemical><Chemical><RegistryNumber>2968PHW8QP</RegistryNumber><NameOfSubstance UI="D019343">Citric Acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>7440-31-5</RegistryNumber><NameOfSubstance UI="D014001">Tin</NameOfSubstance></Chemical><Chemical><RegistryNumber>8NY9L8837D</RegistryNumber><NameOfSubstance UI="C495399">Olaflur</NameOfSubstance></Chemical><Chemical><RegistryNumber>8ZYQ1474W7</RegistryNumber><NameOfSubstance UI="D012969">Sodium Fluoride</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.24.-</RegistryNumber><NameOfSubstance UI="D017364">Collagenases</NameOfSubstance></Chemical><Chemical><RegistryNumber>Q80VPU408O</RegistryNumber><NameOfSubstance UI="D005459">Fluorides</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D011232" MajorTopicYN="N">Chemical Precipitation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019343" MajorTopicYN="N">Citric Acid</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017364" MajorTopicYN="N">Collagenases</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003804" MajorTopicYN="N">Dentin</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003959" MajorTopicYN="N">Diamines</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005459" MajorTopicYN="N">Fluorides</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007091" MajorTopicYN="N">Image Processing, Computer-Assisted</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D021621" MajorTopicYN="N">Imaging, Three-Dimensional</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008855" MajorTopicYN="N">Microscopy, Electron, Scanning</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012969" MajorTopicYN="N">Sodium Fluoride</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013052" MajorTopicYN="N">Spectrometry, X-Ray Emission</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014001" MajorTopicYN="N">Tin</DescriptorName><QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014002" MajorTopicYN="N">Tin Fluorides</DescriptorName><QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017001" MajorTopicYN="N">Tooth Demineralization</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014077" MajorTopicYN="N">Tooth Erosion</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014089" MajorTopicYN="N">Tooth Remineralization</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>7</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>7</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>12</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">20662911</ArticleId><ArticleId IdType="pii">EOS742</ArticleId><ArticleId IdType="doi">10.1111/j.1600-0722.2010.00742.x</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Cocks, Ann Kristin" sort="Cocks, Ann Kristin" uniqKey="Cocks A" first="Ann-Kristin" last="Cocks">Ann-Kristin Cocks</name><name sortKey="Hardt, Martin" sort="Hardt, Martin" uniqKey="Hardt M" first="Martin" last="Hardt">Martin Hardt</name><name sortKey="Klimek, Joachim" sort="Klimek, Joachim" uniqKey="Klimek J" first="Joachim" last="Klimek">Joachim Klimek</name><name sortKey="Lussi, Adrian" sort="Lussi, Adrian" uniqKey="Lussi A" first="Adrian" last="Lussi">Adrian Lussi</name><name sortKey="Schlueter, Nadine" sort="Schlueter, Nadine" uniqKey="Schlueter N" first="Nadine" last="Schlueter">Nadine Schlueter</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Ganss, Carolina" sort="Ganss, Carolina" uniqKey="Ganss C" first="Carolina" last="Ganss">Carolina Ganss</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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